Orthologs are genes that have started diverging through a speciation event, and play an important role in many bioinformatics applications such as gene function prediction, species tree reconstruction or comparative analyses.
The SIB-funded initiative, SwissOrthology, is aimed at serving the orthology community— both users and method-developers. OMA (“Orthologous MAtrix”) and OrthoDB are two world wide leading resources which both provide precomputed gene orthology and stand alone software for custom orthology analyses. SwissOrthology is a joint collaboration involving both groups.
For feedback, suggestions and questions, please contact us on info@swissorthology.ch.
The SwissOrthology project supports the vital maintenance and development of OMA and OrthoDB by helping of keeping both of the resources updated.
SwissOrthology provides functionality for orthology method-developers and users to retrieve consensus orthology calls derived from OMA and OrthoDB. This uses federated SPARQL queries as a backend to facilitate speedy lookups.
SwissOrthology serves as a joint interface between both resources to search for hierarchical orthologs groups for a UniProt protein.
SwissOrthology provides guidance to help prospective users determine which platform is best suited to their needs in terms of type of homologs, species, and analyses.